Epidemiology
Etiology
Hypogonadotropic hypogonadism with hyposmia/anosmia
Pathophysiology
- Defective migration of GnRH-releasing neurons from the olfactory bulbs to the hypothalamic preoptic nuclei → ↓ GnRH secretion and underdevelopment of the olfactory bulbs
- ↓ GnRH → ↓ pituitary secretion of FSH and LH → ↓ testosterone in male individuals and ↓ estrogen in female individuals
Clinical features
- Anosmia or hyposmia
- Infertility
Diagnostics
<% tp.file.cursor() %>
Treatment
<% tp.file.cursor() %>