See Osteogenesis imperfecta

Tip

• Compare with ligaments, which are made of elastin.
• Ligaments attach bone to bone, and tendons attach muscle to bone.
• Connect presence of elastin with Marfan syndrome
  • FBN1 can disrupt the normal regulation of TGF-β → Tall stature
  • Skin → Skin hyperextensibility
  • Large arteries → aortic dilation, aneurysms, or dissection
  • Elastic ligaments → Joint hypermobility
  • Lung → Increased risk of spontaneous pneumothorax

Deficient in vascular type of Ehlers-Danlos syndrome (threE D).

---

See Goodpasture syndrome