Epidemiology

Etiology

Intermittent UV exposure is the most significant risk factor
- As opposed to cumulative UV exposure, which is a recognized risk factor for cSCC.

Nonhealing well-circumscribed pearly papule, nodule, or plaque with rolled borders, telangiectasia, and/or central umbilication
Typically located in areas with sun exposure; most commonly on the face and neck
Often painless
Lesions gradually increase in size (indolent growth)
Metastasizes rarely (< 1%); if lack of treatment, can spread to lymph nodes, soft tissue, lungs, and bone

Papule or nodule with the following:
- Pink or skin-colored papule, shiny with a pearl-like appearance
- Rolled borders
- Central depression, erosion, or ulceration (rodent ulcer)
- Superficial telangiectasias with arborizing pattern (tree-like branching)
Most commonly located on the face, especially the nose