• In warm AIHA - we have IgG which is much better fits for splenic macrophage FC receptor - so it causes more extravascular hemolysis.
  • In cold AIHA IgM is much better activates complement in the blood - intravascular hemolysis.

But basically they all cause some degree of both intra and extravascular hemolysis

If it’s cold- stay inside If it’s warm- go outside & play