Antidepressant overdose

Tricyclic antidepressant overdose

Mechanism of action

• Cardiac fast sodium channel inhibition
• Muscarinic ACh receptor inhibition

Clinical features

• Anticholinergic syndrome (e.g., hyperthermia, delirium, ileus, urinary retention)
• Cardiotoxicity: hypotension, tachycardia, arrhythmias
• Neurotoxicity
  • Altered mental status (e.g., lethargy, coma)
  • Seizures
  • Respiratory depression