• Zone 1: The periportal zone
  • Is best oxygenated and, therefore, is most resistant to ischemia.
  • Affected first in viral hepatitis and toxic substance ingestion, e.g., cocaine.
• Zone 2: intermediate zone (liver): affected in yellow fever

Mnemonic

Zone II is affected in yellow fever.

• Zone 3: pericentral vein/centrilobular zone
  • The least oxygenated zone, and thus most susceptible to ischemia
  • Most sensitive to metabolic toxins (e.g., ethanol, CCl4, halothane, rifampin, acetaminophen)
  • Site of alcoholic hepatitis
  • Has the highest amount of cytochrome P-450