Dupuytren contracture (palmar fibromatosis) is a fibroproliferative disorder of the palmar fascia
Injury (trauma/ischemia) to the palmar fascia triggers myofibroblasts → fibroblast proliferation and collagen (collagen type III) deposition → thickening of the palmar fascia → formation of nodules in the palmar fascia
The nodules are adherent to the overlying dermis → characteristic puckering of palmar skin
Clinical features
The 4th and 5th fingers are most commonly involved
Skin puckering near the proximal flexor crease: earliest sign
