Nondepolarizing NMJ blockers (nondepolarizing muscle relaxants)

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Mechanism of action

• Compete with ACh to bind with the (nicotinic) ACh receptors at the motor end plate (competitive antagonists) → prevention of motor end plate depolarization (nondepolarization block)

Agents

• Rocuronium
• Vecuronium
• Atracurium

Indications

• Rapid-sequence induction of anesthesia when succinylcholine is contraindicated