most common location is the cerebellum → cerebellar defects (e.g., broad-based gait)
cerebellar vermis (midline) → truncal ataxia
Invasion or compression of the 4th ventricle → noncommunicating hydrocephalus → features of raised intracranial pressure (e.g., papilledema, vomiting, headache)
Drop metastases to the spinal cord are common → paraplegia
Diagnostics
Synaptophysin ⊕
A neuron marker found in synaptic vesicles in the central nervous system and neuroendocrine cells. Used as a biomarker for tumors of neuroendocrine origin.
