• Definition: gastritis featuring massive enlargement of the mucosal folds
• Pathophysiology
  • Foveolar hyperplasia leads to:
    • Increased mucus production → loss of protein → peripheral edema
    • Atrophy of parietal cells → decreased gastric acid production
    • Hyperplasia of gastric rugae
• Clinical features
  • Dyspeptic symptoms (i.e., abdominal pain, nausea, vomiting, diarrhea, weight loss)
  • Protein-loss gastropathy → hypoalbuminemia and peripheral edema
• Diagnostics: based on endoscopic and histopathological findings
  • Endoscopic findings: prominent rugae in the gastric fundus
  • Histopathological findings: foveolar hyperplasia and parietal cell atrophy