The only single-stranded DNA (ssDNA) virus!
Pathophysiology
- Parvovirus B19 binds to the P antigen (globoside) on erythroid progenitor cells → cellular invasion → viral DNA enters the nucleus of erythroid cells → viral DNA replication → cytotoxicity → clinical manifestations + transient cessation of erythropoiesis
Clinical features
- Mild respiratory symptoms
- Rash
- Erythema infectiosum (fifth disease)
- Erythema infectiosum (fifth disease)
- Parvovirus B19-associated arthritis
- Severe anemia or transient aplastic crisis
- Hydrops fetalis
- Parvovirus B19 is a TORCH infection that can cause fetal death and miscarriage.