The only single-stranded DNA (ssDNA) virus!

Pathophysiology


  • Parvovirus B19 binds to the P antigen (globoside) on erythroid progenitor cells → cellular invasion → viral DNA enters the nucleus of erythroid cells → viral DNA replication → cytotoxicity → clinical manifestations + transient cessation of erythropoiesis

Clinical features


  • Mild respiratory symptoms
  • Rash
    • Erythema infectiosum (fifth disease) Pasted image 20250320105952.png
  • Parvovirus B19-associated arthritis
  • Severe anemia or transient aplastic crisis
  • Hydrops fetalis
    • Parvovirus B19 is a TORCH infection that can cause fetal death and miscarriage.

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