Acromegaly

Epidemiology


Etiology


Pathophysiology


Question

  • IGF-1 is produced primarily by the liver in response to Growth Hormone (GH) stimulation and mediates most of GH's anabolic and growth-promoting effects.
  • Insulin-like growth factor is just a growth hormone, except
    • It binds to insulin receptor, but not metabolizing glucose, thus contributing to glucose intolerance?

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Clinical features


Tip

Consider acromegaly in patients who report having had to increase hat, shoe, glove, and ring sizes in the past!

Diagnostics


Treatment