- Adalimumab, certolizumab, golimumab, infliximab
Anti-TNF-α monoclonal antibody
Add certain goal inflicting TNF-α
Etanercept intercepts TNF the suffix indicates whether the medication is a monoclonal antibody (mab), a receptor molecule (cept), or a kinase inhibitor (nib).
来自dirty medicine，这也是油管上的一个大佬，推荐去围观
- Alemtuzumab
anti-CD52
AL开头的单抗只有它
哎(A)，李(l)咏没(m)了
他的王牌节目—幸运52
治疗：CLL, multiple sclerosis，chronic lymphocytic leukemia
against VEGF
- Bevacizumab
inhibits Blood Vessel formation
Solid tumors (colorectal cancer, renal cell carcinoma), wet age-related macular degeneration
Mnemonic
VEGF ones because we’re talking about liquids coming in (blood vessel) so bevacizumab is like a beverage and ranibizumab is like a river ran.
- Ranibizumab
Bizu两个眼珠 来自Dr.Why
对应Age-related macular degeneration
也可以治疗视网膜病变
唯一针对补体的
- Eculizumab
Complement protein C5
E是第五个字母，所以对应C5
治疗：Paroxysmal nocturnal hemoglobinuria
长得特别奇怪的
- Bortezomib, carfilzomib
FA上mib结尾的就这两个
他们有M倾向
Proteasome inhibitor
induce arrest at G2-M phase and apoptosis
Multiple myeloma, mantle cell lymphoma
Side effect: Peripheral neuropathy, herpes zoster reactivation
7.Palbociclib
-ciclib
Cyclin-dependent kinase inhibitor
medication for the treatment of HR-positive and HER2-negative breast cancer
踢你不
tyrosine kinase inhibitor
8.Erlotinib
EGFR tyrosine kinase inhibitor
Non-small cell lung cancer
Rash, diarrhea
9.Imatinib, dasatinib, nilotinib
Tyrosine kinase inhibitors of bcr-abl
Philadelphia chromosome fusion gene in CML
c-kit (common in GI stromal tumors)
- 特殊Ruxolitinib
JAK1/2 inhibitor
JAK1是Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway
Use: Polycythemia vera
Jack and Rose
前方高能预警
喜欢LU的PD
Lumab就这几个
总体口诀：NP，ADA, 来自李丹大夫，稍稍改良加入故事
- Nivolumab, pembrolizumab
Inhibit PD-1
Mnemonic
Nivolumab, pembrolizumab Project directors love nigger bro.
12.Atezolizumab, durvalumab, avelumab
Inhibit PD-L1
多了个L，更高Level，所以是对应三个药物ADA
来几个简单的平复一下
- Rituximab
against CD20
which is found on most B-cell neoplasms
从一开始做题就会遇到的
- Palivizumab，-vi-/-v-
抗病毒
RSV F protein
- Denosumab
对应RANKL
这个比较特别，骨科的，一般不会弄错
而且-S-代表bone，FA同类单抗里只有它
16.PCSK9 inhibitor
PC=破产，PC只能哭了cry=c，放心没有Kumab的药物，所以只有cumab
Alirocumab, evolocumab
Myalgias, delirium,dementia, other neurocognitive effects
哭得像个傻子（神经症状）
17.Cetuximab, panitumumab
Monoclonal antibodies against EGFR
第一种：Ce，策，湖南话调侃
Pan，盘，代表收拾”、“对付，盘它
两个都是恶搞（eg），所以对应EGFR
第二种：EGFR一个法国公司 Cetuximab类似雪铁龙，citreon, 正好是法国的公司 来自Dr.why
panitumumab
penny to mum，给妈妈钱求妈妈别打（表皮）
第三种：EGFR，一个法国人，Cetuxi吸吐吸（雪茄）来自Dr.why
Stage IV colorectal cancer (wild-type KRAS), head and neck cancer
Rash, elevated LFTs, diarrhea
- Trastuzumab
Tu,对应2，HER-2
Monoclonal antibody against HER-2 (c-erbB2), a tyrosine kinase receptor. Helps kill cancer cells that overexpress HER-2 through inhibition of HER-2 initiated cellular signaling and antibody dependent cytotoxicity.
Kinu是磨咖啡豆的机器，磨出一堆碎屑=牛皮癣 来自Dr.Why
19.Ixekizumab, secukinumab
IL-17A
IX=9，加上后面八个字母，等于17，sec=第二个，跟在IX大哥后面也是对付17的 （就是跟着Ixekizumab混个眼熟）
Psoriasis, psoriatic arthritis
20.ustekinumab
IL-12/IL-23
Psoriasis, psoriatic arthritis
一共11个字母，加上美国12个州，所以是23
21.Natalizumab
a4-integrin
ta= tetragon a，四个a，所以对应a4-integrin
22.Abciximab
心血管系统cardiovascular。example:-cixumab/-cumab
Platelet glycoproteins IIb/IIIa
23.Omalizumab
IgE
Li 对应身份，M翻转一下就是E
24.Dabrafenib, vemurafenib
Small molecule inhibitors of BRAF oncogene ⊕ melanoma. VEmuRAF-enib is for V600Emutated BRAF inhibition. Often co-administered with MEK inhibitors (eg, trametinib).
Metastatic melanoma
- Mepolizumab, reslizumab—against IL-5
hive with eye - IL -5 map - mepolizumab raygun - reslizumab belt - Benralizumab —against IL-5 receptor α
IL表明身份，是免疫相关的，5= 我 = 本美人 Ben，Me（i），Re（N）
26.ipilimumab (anti-CTLA-4 antibody) 来自Dr.Why
1）一匹厉害的母马ipilimumab用四条腿从ct跑到LA
2）春天（CT）的LA，有一匹母马，四条腿
3）这四个字母，一共有四个直线，line-4，L-4，所以对应CTLA-4
- Basiliximab, daclizumab
Monoclonal antibody; blocks IL-2R
B是第二个字母，对应IL-2R
28.Erenumab, fremanezumab and galcanezumab 来自Ishmael
anti-CGRP monoclonal antibodies
era（纪元）+num（数目）；frame（画框）；gal（girl）+cane（拄拐）；记忆画面：在一个年代久远的画框里面有幅画：一个有migraine的女孩因头疼拄着拐杖
29. idarucizumab
idarucizumab can be used to inhibit dabigatran