Epidemiology

  • Sex: ♂ > ♀ (3:1)

Etiology

  • Mechanism: a sudden and severe rise in the esophageal intraluminal pressure results in tearing of the esophageal mucous membrane, as well as the submucosal arteries and veinsPasted image 20231018170534.png
  • Precipitating factors
    • Severe vomiting
  • Predisposing conditions

Pathophysiology


Clinical features

  • May be asymptomatic
  • Epigastric or back pain
  • Hematemesis
    • typically follows a period of severe, bloodless vomiting
  • Possible shock

Diagnostics

EGD

  • Typical findings
    • Often a single longitudinal tear (but multiple tears are possible) in the mucosa at the gastroesophageal junction or in the cardia of the stomach which are limited to the mucosa and submucosa
    • A fibrin crust over the split, a clot, or active bleeding may be evident.Pasted image 20231018170927.png

Differential diagnostics

Characteristics of Gastroesophageal Mural InjuryMallory-Weiss SyndromeBoerhaave Syndrome
EtiologyForceful retchingForceful retching
Mucosal tearTransmural tear
Submucosal venous or arterial plexus bleedingSpillage of esophageal air/fluid into surrounding tissues
Clinical PresentationEpigastric/back painChest/back/epigastric pain
Hematemesis (bright red or coffee-ground)Crepitus, crunching sound (Hamman sign)
Possible hypovolemiaOdynophagia, dyspnea, fever, sepsis
StudiesUpper GI endoscopy confirms diagnosis (& can treat persistent bleeding)Chest x-ray: pneumothorax, pneumomediastinum, pleural effusion
Esophagography or CT scan with water-soluble contrast confirms diagnosis
ManagementAcid suppressionAcid suppression, antibiotics, NPO
Most heal spontaneouslyEmergency surgical consultation

Treatment