M. avium-intracellulare (Mycobacterium avium complex infection)
Clinical features
MAC infection often manifests as disseminated disease and typically occurs in patients with advanced immunosuppression (CD4 counts < 50).
Night sweats, fever, weight loss
Focal lymphadenitis
Abdominal pains, diarrhea
Widespread involvement of the reticuloendothelial system often causes anemia, hepatosplenomegaly, and/or elevated alkaline phosphatase and lactate dehydrogenase.
Histologic findings in the bone marrow include foamy macrophages with intracellular, acid-fast bacilli.
M. marinum
Fish tank granuloma: skin infection usually of the hand that occur in individuals handling fish (e.g., aquarium handlers)