Epidemiology


Etiology


Pathophysiology


Clinical features

Indolent (low-grade)

  • Follicular lymphoma
    • Most common low-grade lymphoma in adults
    • Slowly progressive and painless course with an alternating (waxing and waning) pattern of lymphadenopathy and splenomegaly
    • Translocation t(14;18), which involves the heavy-chain Ig (chromosome 14) and Bcl-2 gene (chromosome 18) → overexpression of Bcl-2 → dysregulation of apoptosis (normally inhibited by Bcl-2)

Aggressive (high-grade)

  • Burkitt lymphoma
    • Most common in children
    • Translocation t(8;14) in 75% of cases: reciprocal translocation involving the c-myc gene (chromosome 8) and heavy-chain Ig locus (chromosome 14) → overactivation of c-myc proto-oncogene → activation of transcription
    • Forms
      • Sporadic: typically located in the abdomen or pelvis
      • Endemic: associated with EBV (most prevalent in equatorial Africa and South America) and is typically located in the maxillary and mandibular bones
      • Immunodeficiency-associated: e.g. HIV infection
    • Starry sky pattern (See below)
    • Nonendemic BL often involves the gastrointestinal tract, which can present as an enlarging abdominal mass with ascites (due to lymph obstruction) and distention and obstruction.

Diagnostics

Tip

Lymphoma arises from mature lymphocytes and often forms tumors in the lymphatic system, leukemia typically originates from immature progenitor cells in the bone marrow and is characterized by abnormal cells circulating in the blood.

Chromosomal translocations

MalignancyPathogenesis
Acute promyelocytic leukemiat(15;17) involving PML & RARA → PML-RARα oncoprotein → myeloid differentiation inhibited
RARα: nuclear receptor involved in myeloid differentiation
PML: fusion forms receptor with dominant negative activity
Burkitt lymphomat(8;14) involving MYC & IGH → MYC overexpression → cell growth
MYC: transcription factor regulating cell growth
IGH: immunoglobulin heavy chain (high expression in B cells)
Chronic myeloid leukemiat(9;22) involving ABL1 & BCR → BCR-ABL1 oncoprotein → cell proliferation
ABL1: nonreceptor tyrosine kinase
BCR: fusion leads to activation
Follicular lymphomat(14;18) involving IGH & BCL2 → BCL2 overexpression → apoptosis evasion
BCL2: antiapoptotic protein
Mantle cell lymphomat(11;14) involving CCND1 & IGH → cyclin D1 overexpression → cell cycle progression
Cyclin D1: regulates cell cycle progression

Pathology

  • Burkitt lymphoma
    • Starry sky patternL66233.jpg
      • Microscopic finding that resembles a starry sky
      • Tingible body macrophages (containing many phagocytized tumor cells) are scattered diffusely within a sheet of uniform neoplastic cells (lymphocytes).

Treatment


Specific regimens