Epidemiology
Etiology
Pathophysiology
Clinical features
Indolent (low-grade)
- Follicular lymphoma
- Most common low-grade lymphoma in adults
- Slowly progressive and painless course with an alternating (waxing and waning) pattern of lymphadenopathy and splenomegaly
- Translocation t(14;18), which involves the heavy-chain Ig (chromosome 14) and Bcl-2 gene (chromosome 18) → overexpression of Bcl-2 → dysregulation of apoptosis (normally inhibited by Bcl-2)
Diagnostics
Tip
Lymphoma arises from mature lymphocytes and often forms tumors in the lymphatic system, leukemia typically originates from immature progenitor cells in the bone marrow and is characterized by abnormal cells circulating in the blood.
Chromosomal translocations
| Malignancy | Pathogenesis |
|---|---|
| Acute promyelocytic leukemia | t(15;17) involving PML & RARA → PML-RARα oncoprotein → myeloid differentiation inhibited RARα: nuclear receptor involved in myeloid differentiation PML: fusion forms receptor with dominant negative activity |
| Burkitt lymphoma | t(8;14) involving MYC & IGH → MYC overexpression → cell growth MYC: transcription factor regulating cell growth IGH: immunoglobulin heavy chain (high expression in B cells) |
| Chronic myeloid leukemia | t(9;22) involving ABL1 & BCR → BCR-ABL1 oncoprotein → cell proliferation ABL1: nonreceptor tyrosine kinase BCR: fusion leads to activation |
| Follicular lymphoma | t(14;18) involving IGH & BCL2 → BCL2 overexpression → apoptosis evasion BCL2: antiapoptotic protein |
| Mantle cell lymphoma | t(11;14) involving CCND1 & IGH → cyclin D1 overexpression → cell cycle progression Cyclin D1: regulates cell cycle progression |
Treatment
Specific regimens
- Hairy cell leukemia
- Chemotherapy with cladribine or pentostatin