Epidemiology Etiology Pathophysiology Clinical features Diagnostics Treatment Ductal-dependent CHDs: a group of CHDs that require the patent ductus arteriosus (PDA), which supplies either pulmonary or systemic circulation, to sustain life until surgery can be performed PDA supplies systemic circulation in the following: Transposition of the great arteries Hypoplastic left heart syndrome Coarctation of the aorta PDA supplies pulmonary circulation in the following: Tricuspid atresia Treatment: administration of prostaglandin E1 (PGE1) infusion Example: IV alprostadil infusion Mechanism of action: prevents the ductus arteriosus from closing, creating an intentional shunt to allow mixing of deoxygenated with oxygenated blood
