Adverse effects

The resultant increase in gastric pH leads to increased gastrin formation, which, over time, can lead to hypertrophy of ECL and parietal cells. After chronic use (eg, >8 weeks), abrupt cessation of the PPI can trigger rebound gastric acid hypersecretion by the hyperfunctioning parietal cells, leading to reflux symptoms; PPIs can be slowly tapered to prevent this adverse effect.