Epidemiology
Etiology
Pathophysiology
Hepatic degradation of ethanol to acetyl-CoA by alcohol dehydrogenase results in NADH excess (see Alcohol Metabolism) → ↑ NADH drives the formation of glycerol 3-phosphate (G3P) from dihydroxyacetone phosphate (DHAP) → ↑ in both G3P and fatty acids causes increased triglyceride synthesis in the liver and accompanying inflammation → steatohepatitis → chronic inflammation leads to hepatic fibrosis and sclerosis → portal hypertension and eventually cirrhosis