Amanita phalloides (death cap mushroom)

• Pathophysiology
  • α-amanitin: blocks RNA polymerase → inhibition of mRNA transcription and protein synthesis → apoptosis
• Clinical features
  • After 6–24 hours: gastrointestinal symptoms (diarrhea, vomiting, abdominal cramps) that resolve 24–36 hours after ingestion
  • After 2–4 days: renal and liver failure
  • Ingestion of a single cap may be lethal