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Membranoproliferative = mesangial cell proliferate

• Primary disease occurs mainly in children

Classifications

• Immunoglobulin (IG)-mediated membranoproliferative glomerulonephritis (type 1 MPGN)
  • Associated with SLE, monoclonal gammopathy
• Complement-mediated membranoproliferative glomerulonephritis (type 2 MPGN: associated with dense deposit disease (IgG antibodies that stabilize C3 convertase, i.e., C3 nephritic factor, cause a persistent complement activation, leading to a depletion of C3)