Epidemiology
Etiology
Pathophysiology
Clinical features
Diagnostics
Treatment
- Direct arteriolar vasodilators
- Mechanism
- Increase the release of cGMP → relaxation of smooth muscle → vasodilation → ↓ afterload
- Agents
- Hydralazine
- Hydralazine is a treatment option in pregnant patients.
- Minoxidil
- Hydralazine
- Mechanism
Warning
In patients with long-standing hypertension, a chronic autoregulatory shift in the blood pressure–flow relationship occurs, affording less perfusion (flow) at any given pressure. Therefore, excessively rapid correction of blood pressure toward normal may induce relative ischemia.