- B-cell immunodeficiencies (pyogenic and sinopulmonary infections, especially by encapsulated bacteria. See Asplenia)
- X-linked (Bruton) agammaglobulinemia
- Selective IgA deficiency
- Common variable immunodeficiency
- T-cell immunodeficiencies (more abnormalities)
- DiGeorge syndrome
- Autosomal dominant hyper-IgE syndrome (Job syndrome)
- IL-12 receptor deficiency
- Chronic mucocutaneous candidiasis
- IPEX syndrome
- Combined immunodeficiencies
- Neutrophil and phagocyte disorders
- Chronic granulomatous disease (CGD)
- Leukocyte adhesion deficiency type 1
- Chédiak-Higashi syndrome
- Myeloperoxidase deficiency
| Condition | Characteristic features |
|---|---|
| Ataxia-telangiectasia | - Ataxia |
| - Telangiectasias | |
| - Sinopulmonary infections | |
| Chédiak-Higashi syndrome | - Oculocutaneous albinism |
| - Pyogenic infections | |
| - Progressive neurologic dysfunction | |
| Chronic granulomatous disease | - Severe bacterial & fungal infections |
| - Granuloma formation | |
| DiGeorge syndrome | - Congenital heart disease |
| - Dysmorphic facies | |
| - Hypocalcemia | |
| Severe combined immunodeficiency | - Severe bacterial & viral infections in infancy |
| - Chronic diarrhea | |
| - Mucocutaneous candidiasis | |
| Terminal complement deficiency | - Recurrent Neisseria infection |
| Wiskott-Aldrich syndrome | - Recurrent infections that worsen with age |
| - Easy bleeding | |
| - Eczema |