Epidemiology
- Most common type of sex cord-stromal malignancy (∼ 90%)
- Peak age: 50–55 years
Etiology
Pathophysiology
Clinical features
- Symptoms caused by estrogen and/or progesterone secretion
- Adult subtype: menstrual irregularities (e.g., postmenopausal bleeding, endometrial hyperplasia with metrorrhagia)
- Juvenile subtype: precocious puberty
- Breast tenderness
- Associated with increased risk of endometrial cancer
Diagnostics
Pathology
- Call-Exner bodies: granulosa cells arranged in clusters surrounding a central cavity with eosinophilic secretions, resembling primordial follicles
Mnemonic
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