Epidemiology
Etiology
Pathophysiology
- Multiple somatic mutations of TSH receptor occur in long-standing goiters (> 60% of cases) → autonomous functioning of some nodules (toxic MNG) → hyperthyroidism (due to ↑ release of both T3 and T4)
Clinical features
- Painless goiter with multiple palpable nodules
- Symptoms of thyrotoxicosis
Diagnostics
- Increased radioiodine uptake by multiple hyperfunctioning (hot) nodules