• Pathophysiology: An immunoreaction to hepatic halothane metabolites is suspected.
• Clinical features
  • Occurs 2 days to 3 weeks after halothane exposure
  • Signs of acute hepatitis (e.g., jaundice, fever, vomiting, hepatomegaly)
  • Rash, arthralgias
• Diagnostics: diagnosis of exclusion
  • Possible laboratory findings: ↑ eosinophils, ↑ serum transaminases , ↑ bilirubin, ↑ alkaline phosphatase
  • Biopsy shows massive centrilobular hepatic necrosis