Epidemiology
Etiology
Pathophysiology
Clinical features
Subtypes and variants
Food protein-induced allergic proctocolitis of infancy (FPIAP)
- Definition: a type of delayed inflammatory non-IgE-mediated food allergy typically seen in young infants that affects the distal colon
- Epidemiology: primarily affects young infants (typically manifests at 2–8 weeks of age)
- Etiology
- Hypersensitivity reaction to certain foods, most commonly cow’s milk, followed by soy protein, rice, and eggs
- Associated with a personal and family history of atopy
- Clinical features
- Insidious progression of symptoms over several months
- Rectal bleeding
- Increased stool frequency
- Streaks of mucus in the stool
- Abdominal pain
- Affected infants typically appear otherwise healthy.
- Histopathology findings include infiltration of eosinophils within the lamina propria and muscularis mucosa.
Diagnostics
Treatment