Pharmacodynamics

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1. Antiinflammatory and immunosuppressive
   • Acute effects (within minutes)
     • ↓ Vasodilation and ↓ capillary permeability
     • ↓ Leukocyte migration to inflammatory foci
   • Long-term effects (within hours) : Glucocorticoids bind to cytoplasmic glucocorticoid receptors (GRs)
     • Inhibition of neutrophil apoptosis and demargination (loss of neutrophil binding to adhesive endothelial integrin molecules) → neutrophilic leukocytosis

Adverse effects

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