Definition

  • A form of chronic communicating hydrocephalus that primarily affects adults > 60 years of age
  • Characterized by a distinct clinical triad (gait apraxia, dementia, and urinary incontinence) and normal or only mildly elevated ICP

Etiology

Idiopathic (iNPH, most common in adults > 60 years of age)


Pathophysiology

  • ↓ CSF absorption → CSF accumulation → enlargement of the ventricle → stretching the descending cortical fibers (corona radiata) and compression of cortex and basal ganglia
  • ICP: normal or only mildly elevated because ventricular dilation compensates for the slow accumulation of CSFL52716.jpg

Clinical features

A classic triad of:

  • Gait abnormalities: frequent falls, broad-based gait with short shuffling steps (gait apraxia, also known as magnetic gait)
  • Dementia: short attention span, loss of motivation, disturbances of spatial orientation
  • Urinary incontinence

Tip

Normal pressure hydrocephalus does not manifest with signs of increased ICP (e.g., headache, papilledema).

Mnemonic

Patients present with the classic triad of the 3 Ws: Wet (urinary incontinence), Wacky (dementia), and Wobbly (gait apraxia).


Diagnostics

  • MRI
    • Ventriculomegaly without to sulcal enlargementL23262.jpg

Treatment