Hemophilia

Etiology

Hemophilia usually affects males, as it is primarily an X-linked recessive disease.

Clinical features

  1. Repeated hemarthrosis (e.g., knee joint) → hemophilic arthropathy (i.e., destruction of the joint due to repeated hemarthrosis)
  2. Oral mucosa bleeding, epistaxis, excessive bleeding following small procedures (e.g., dentist procedures)
  3. Hemophilia C does not typically manifest with spontaneous bleeding, hemarthrosis, or deep tissue bleeding.