Agents

• Cisplatin
• Carboplatin
• Oxaliplatin

Mechanism

Cross-links between DNA strands → ↓ DNA replication

Indications

• Lymphomas
• Solid tumors
  • Cervical cancer (cisplatin)
  • Osteosarcoma (cisplatin)

Adverse effects

• Nephrotoxicity (may manifest as Fanconi syndrome)
• Neurotoxicity (including peripheral neuropathies)
• Ototoxicity