Definition

a cutaneous T-cell lymphoma with leukemic dissemination of mutated T cells

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Epidemiology

advanced form of mycosis fungoides or arise de novo

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Clinical features

• Systemic skin lesions
  • Erythroderma accompanied by palmar and plantar hyperkeratosis
  • Intense pruritus
• Generalized lymphadenopathy

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Diagnostics

atypical T cells (Sézary cells) on peripheral blood smear