Physiological changes during pregnancy

Renal system

• ↑ Renal plasma flow → ↑ GFR → ↓ BUN and creatinine
  • Increased cardiac output leads to increased renal perfusion.
  • Therefore, serum creatinine levels considered normal in nonpregnant patients (eg, 1.0 mg/dL) represent significant renal dysfunction in this population.
• ↑ Glucose levels in urine: Increased glomerular filtration results in overload of the glucose carrier responsible for its resorption.