- Neutropenia: ANC < 500/mcL OR expected to decrease to < 500/mcL within 48 hours
- Fever: single oral temperature ≥ 38.3°C (101°F) OR ≥ 38°C (100.4°F) for at least 1 hour
Epidemiology
Etiology
- Low ANC: typically results from cancer therapy
- Source of fever: neutropenic fever without an identifiable source (eg, normal chest x-ray, normal urine culture, normal examination) is believed to be caused by translocation of endogenous bacteria into the bloodstream from mucositis, which results from chemotherapy-induced disruption of the gastrointestinal epithelium.
Pathophysiology
Clinical features
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Diagnostics
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Treatment
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