• Triggers: anti-inflammatory medications, penicillins, and cephalosporins
  • Pathogenesis
  • Manifestations
    • Sudden onset (within hours of exposure)
    • Anemia: fatigue, pallor, dyspnea
    • Hemolysis: jaundice, dark urine, abdomen/back pain
      • ↑ Reticulocytes, indirect bilirubin & LDH
      • ↓ Haptoglobin
      • Spherocytes on peripheral blood smear
      • +Direct Coombs test (anti-IgG, anti-C3)
  • Treatment
    • Discontinue offending drug